Reply to “Studies on Influenza Virus Transmission between Ferrets: the Public Health Risks Revisited”
نویسندگان
چکیده
We are gratified that Ron Fouchier has joined (1) the important effort to quantify the risks (2–5) of the creation of potential pandemic pathogens, including ferret-transmissible variants of influenza A/H5N1. However, we disagree with many aspects of his assessment. As in our article and Fouchier’s letter, here we proceed through the calculation, starting with probability of laboratory-acquired infections and the conditional probability of sparking a pandemic given such an infection and concluding with the consequences thereof. We then discuss some more general considerations.
منابع مشابه
Studies on Influenza Virus Transmission between Ferrets: the Public Health Risks Revisited
Lipsitch and Inglesby recently estimated the potential public health risks associated with research on influenza virus transmission via respiratory droplets or aerosols between ferrets, leading them to conclude that such research is too risky to be conducted (1). The authors of that and other publications (2–4) estimated the probability of laboratory-acquired infections (LAIs) and onward transm...
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BACKGROUND The emergence of zoonotic viruses in domestic animals is a significant public health concern. Canine influenza virus (CIV) H3N2 is a virus that can infect companion animals and is, therefore, a potential public health concern. OBJECTIVE This study investigated the inter- and intraspecies transmission of CIV among dogs, cats, and ferrets, under laboratory conditions, to determine wh...
متن کاملThe future of research and publication on altered H5N1 viruses.
Recently, we and others obtained experimental evidence that highly pathogenic avian influenza virus subtype H5 can acquire the ability to transmit via aerosols between ferrets. Upon submission of manuscripts describing the results of these studies, the US National Science Advisory Board for Biosecurity was consulted and recommended that the main conclusions of the work be published but without ...
متن کاملScience Should Be in the Public Domain
Variants of avian influenza H5N1 virus that are transmitted by the airborne route among ferrets have been identified. The National Science Advisory Board for Biosecurity has advised against publication of the details of the methods used to obtain these viruses and the amino acid changes that lead to transmission in ferrets. This decision is not based on sound scientific principles and risks set...
متن کاملTransmission of Aerosolized Seasonal H1N1 Influenza A to Ferrets
Influenza virus is a major cause of morbidity and mortality worldwide, yet little quantitative understanding of transmission is available to guide evidence-based public health practice. Recent studies of influenza non-contact transmission between ferrets and guinea pigs have provided insights into the relative transmission efficiencies of pandemic and seasonal strains, but the infecting dose an...
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عنوان ژورنال:
دوره 6 شماره
صفحات -
تاریخ انتشار 2015